Then, depending on whether your B12 deficiency is related to your diet, you'll either require B12 tablets between meals or regular injections. It's important for vitamin B12 or folate deficiency anaemia to be diagnosed and treated as soon as possible.

a specialist in nutrition (a dietitian) – if your GP suspects you have a vitamin B12 or folate deficiency caused by a poor diet Zhang S, Hunter DJ, Hankinson SE, Giovannucci EL, Rosner BA, Colditz GA, Speizer FE, Willett WC. A prospective study of folate intake and the risk of breast cancer. JAMA. 1999 May 5;281(17):1632-7. The general population can get enough folate from foods where folate occurs naturally, as well as foods fortified with folic acid. However, women of childbearing age cannot get enough folate from these sources to prevent NTDs, so it is recommended that people who could become pregnant take a folate supplement. The indication is to take folate for 3 months before conception and to continue taking it for at least the first 3 months of pregnancy to prevent having a baby with neural tube defects (NTDs), a malformation that develops in the first 28 days of pregnancy, before many women even know that they’re pregnant. 22, 23While it’s ideal that people obtain nutrients from food, the population can’t universally assume that it can rely on the diet for food folates. THF is a critical player in folate metabolism as a folate-acceptor molecule. THF is first converted to 5,10-methylene-THF and then later is reduced to 5-MTHF by MTHFR. 22 It is recommended to take folic acid while you're trying for a baby (ideally for 3 months before) and during the first 12 weeks of pregnancy.

The usual dose for adults and children is 5mg once a week, on a different day of the week to your methotrexate.

Tests for pernicious anaemia are not always conclusive, but can often give your GP a good idea of whether you have the condition. Referral to a specialist Nutrition C for FS and A. Questions and answers on dietary supplements. FDA. Published online October 26, 2022. It is essential to carefully read the ingredient list and nutrition facts panel of a supplement to know which ingredients and how much of each ingredient is included, relative to the recommended daily value of that ingredient. Please bring the supplement label to a healthcare provider to review the different ingredients contained in the supplement and any potential interactions between these ingredients and other supplements and medications you are taking.

NOW Folic Acid also has 25 mcg (1,042% daily value) of vitamin B-12 as cyanocobalamin. It can especially be important for those following a vegan diet to take B12 along with folate, as folate supplements could hide a vitamin B12 deficiency.

5-MTHF And Depression

Mazza et al demonstrated the capacity of 400 μg of Quatrefolic, in conjunction with B6 and B12, to lower Hcy serum levels better than conventional vitamin supplementation with highly dosed folic acid (5 mg/day). Quatrefolic was tested on hypertensive people with a low cardiovascular risk—104 patients with HCys of ≥15 μmol/L.